Description

BayesMendel is an R package for Mendelian risk prediction. It includes R implementation of the BRCAPRO, MMRpro and PancPRO models, as well as functionality to adapt BRCAPRO, MMRpro and PancPRO to specific populations and to develop new Mendelian risk prediction models for other syndromes. The MELAPRO model is currently under development and not yet available in the R package.

New to Version 2.0-1:

• Pedigrees of any size with relatives of any degree can be included. Previous versions only included first and second degree relatives in the calculation.
• Updated penetrances for breast/ovarian and colorectal/endometrial cancers for homozygous germline mutation carriers.
• MMRpro now incorporates colorectal tumor location (proximal or distal) into the calculation
• Competing risks for non-breast and non-ovarian cancers are included in BRCAPRO calculations.

Download BayesMendel_2.0-1

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First time R users:

If R is not installed on your computer, you need to install it before you can use BayesMendel. R is free and open source and available at the CRAN website. Once you get there, if you use Windows, click on "Windows (95 and later)" then click on "base" then click on "rw1091.exe" this will start the download. Once you have the exe file, click on it and it will install. Once installed, click to start.If you use linux or a mac, you probably know what to do once you get to CRAN.

At this point the best thing to do is to spend a day or two familiarizing yourself with R. In addition to the extensive materials provided at CRAN, a couple of very good places to get a quick start are the Statistical Computing Class at JHSPH or the R course by Bates and Lumley. Among the things you will learn is how to install a package (it's an easy thing to do). BayesMendel installs like any other package.

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