Zhe Zhang

Oncology Biostatistics Sidney Kimmel Cancer Center Johns Hopkins University 550 N. Broadway, Suite 1131 Baltimore, MD 2105

Tel: (410) 502-0946 (W) (410) 419-9820 (M) Email: zzhang16@jhmi.edu

SKILLS
	Statistical Packages § SAS (BASE, STAT, MACRO, GRAPH, SQL) § R / S-Plus § Stata § StatXact § WinBugs Design Packages § Power And Precision § ExpDesign Studio § PASS Other § Database: SQL, MS Access § Microsoft Excel, Word, PowerPoint § Operating System: Windows	Statistical Methods § Survival Analysis § Categorical Data Analysis § Longitudinal Data Analysis § Nonparametric Methods § Regression Analysis § Generalized Linear Models § Multivariate Analysis § Quality of Life Assessment § Experimental Design and Data Analysis § Microarray Data Analysis
EDUCATION
Master of Science, Statistics, 1/ 2000 – 8/2001 Mississippi State University, Starkville, MS			GPA: 3.85/4.0
Master of Science, Biochemistry, 9/1995 – 7/1998 Xiamen University, Xiamen, China			GPA: 3.75/4.0
Bachelor of Science, Biochemistry, 9/1991 – 7/1995 Xiamen University, Xiamen, China			GPA: 3.60/4.0
EXPERIENCE
Biostatistician Oncology Biostatistics Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, MD			3/2004 – Present
	§ Collaborate with cancer center investigators on clinical trails and laboratory studies: from study design, protocol development, grant application, data analysis, report writing to manuscript preparation § Participate in the lymphoma and breast cancer SPORE (Special Programs Of Research Excellence, established by NCI) programs for statistical inputs and supports § Perform statistical analysis for high-dimension microarray data and assist in novel methodology development and implementation
Biostatistician St. Jude Children’s Research Hospital, Memphis, TN			2/2002 – 2/2004
	§ Regularly conducted statistical analyses and generated reports for the St.Jude Data Safety Monitoring Board § Clinical trial (Phase II/III): Total therapy for newly diagnosed patients with acute lymphoblastic leukemia § Clinical trial (Phase III): Hematopoietic stem cell transplantation for patients with hematologic malignancies – a comparison of T-cell depleted bone marrow with unmanipulated bone marrow § Provided statistical analyses and reports for the phase II/III study of pediatric patients with relapsed or refractory acute lymphoblastic leukemia § Performed analyses in the project of improving the outcome of children acute lymphoblastic leukemia: treatment abandonment in Honduras § Participated in a Pharmocogenetics study: the association between genetic polymorphisms in 16 loci and the minimal residual disease to identify genotypic predictor of MRD status § Worked on the study of minimal residual disease in the acute myeloid leukemia protocol § Provided statistical support for Wiskott-Aldrich Sydrome (WAS) cytokine in mice gene transfer studies § Worked closely with the clinical investigator to accomplish the project of the comparison of auto and manual absolute neutrophil and phagocyte counts
Graduate Research Assistant Mississippi State University, Starkville, MS			4/2001 – 8/2001
	§ Participated in developing a system to reasonably evaluate the online lecture in Epidemiology using quality control adjustments and advanced nonparametric methods with database (MS Access) involved (NIH funding)
Graduate Teaching Assistant Teaching Learning Center, Mississippi State University, Starkville, MS			8/2000 – 5/2001
	§ Provided statistical and mathematical assistance for students at MSU
Master Project Department of Mathematics and Statistics Mississippi State University, Starkville, MS			2/2001 – 8/2001
	§ Analyzed the censored life time data (breast cancer) using survival analysis approach
Graduate Research Assistant Department of Biochemistry and Molecular Biology Mississippi State University, Starkville, MS			8/1998 – 12/1999
	Identified and sequenced a resistant gene to A.flavus of maize
AWARDS
	§ The Award of Outstanding Graduate Student in Statistics Department of Mathematics and Statistics, Mississippi State University, MS, 2000 - 2001 § Scholarship for Master program Department of Mathematics and Statistics, Mississippi State University, MS, 8/2000 – 7/2001 § The First Prize of Achievements in Science Research for Graduates Xiamen University, Xiamen, China, 1998
PUBLICATIONS
	§ Metzger M, Howard S, Fu L, Pena A, Stefan R, Hancock M, Zhang Z, Pui CH, Williams J, and Ribeiro R. Improving the Outcome of Childhood Acute Lymphoblastic Leukemia in Countries with Limited Resources: Insights from Honduras. Lancet, 362: 706-708, 2003. § Hijiya N, Gajjar A, Zhang Z, Sandlund J, Ribeiro R, Rubnitz J, Jeha S, Cheng C, Raimondi S, Behm F, Rivera G, Relling M, and Pui CH. Low-dose Oral Etoposide-based Induction Regimen for Children with Acute Lymphoblastic Leukemia in First Bone Marrow Relapse. Leukemia, 18 (10):1581-1586, 2004. § Hijiya N, Onciu M, Howard S, Zhang Z, Cheng C, Sandlund J, Kyzer E, Behm F, Pui CH. Utility of Automated Counting to Determine Absolute Neutrophil Counts and Absolute Phagocyte Counts for Pediatric Cancer Treatment Protocols. Cancer, 101 (11): 2681-2686, 2004. § Kasamon YL, Jones RJ, Diehl LF, Nayer H, Borowitz MJ, Garrett-Mayer E, Ambinder RF, Abrams RA, Zhang Z, Flinn IW. Outcomes of Autologous and Allogeneic Blood or Marrow Transplantation for Mantle Cell Lymphoma. Biology of Blood and Marrow Transplantation, 11: 39-46, 2005 § Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA Jr. Spermine oxidase SMO (PAOh1), not N1-acetylpolyamine oxidase (PAO) is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J. Biol. Chem., 280 (48): 39843-39851, 2005 § Murata S, Kominsky SL, Vali M, Korz D, Huso D, Baker S., Barber J, Jaffee E, Reilly RT, Garrett E, Zhang Z, Sukumar S. Ductal access for prevention and therapy of mammary tumors. Clin Cancer Res., Jan 15, 2006. § Fackler MJ, Malone K, Zhang Z, Schilling E, Garrett-Mayer E, Swift-Scanlan T, Lange J, Nayar R, Davidson N, Khan S, Sukumar S. Quantitative multiplex methylation-specific PCR analysis doubles detection of tumor cells in breast ductal fluid. Clin Cancer Res., 12 (11) Jun 1, 2006.