Chapter 1:
Preliminaries
Chapter 2:
Clinical Trials as Research
Chapter 3:
Why Clinical Trials Are Ethical
Chapter 4:
Contexts for Clinical Trials
Chapter 5:
Statistical Perspectives
Chapter 6:
Clinical Trials as Experimental Designs
Chapter 7:
Random Error and Bias
Chapter 8:
Objectives and Outcomes
Chapter 9:
Translational Clinical Trials
Chapter 10:
Dose-Finding Designs
Chapter 11:
Power and Sample Size
Chapter 12:
The Study Cohort
Chapter 13:
Treatment Allocation
Chapter 14:
Treatment Effects Monitoring
Chapter 15:
Counting Subjects and Events
Chapter 16:
Estimating Clinical Effects
Chapter 17:
Prognostic Factor Analyses
Chapter 18:
Reporting and Authorship
Chapter 19:
Factorial Designs
Chapter 20:
Crossover Designs
Chapter 21:
Meta-Analyses
Chapter 22:
Misconduct and Fraud in Clinical Research
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